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COX-2 inhibitor - Wikipedia, the free encyclopedia
In a six week long study comparing Vioxx 25 mg once daily, Vioxx 12.5 mg once daily, Celebrex 200 mg once daily, and paracetamol/acetaminophen 1000 mg .
http://en.wikipedia.org/wiki/COX-2_inhibitor

Celebrex And Vioxx Issue Rival Reports
The six- week, multi-center, randomized study compared: Vioxx 12.5 mg. once- daily; Vioxx 25 mg. once-daily; Celebrex 200 mg. once-daily; acetaminophen .
http://arthritis.about.com/cs/cox/a/celebvioxxrival.htm

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Second, Replicate Study Favors Celebrex
Study compares Celebrex and Vioxx and their cardiovascular side effects. . Celebrex 200 mg. . In the replicate study, 14.9% of patients taking Vioxx experienced increases in systolic blood pressure compared to 6.9% of patients taking Celebrex. . happening in the real world, 83% of Vioxx scripts are for the 25 mg. dose".
http://arthritis.about.com/od/celebrex/a/coxhypertension.htm

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APPENDIX H
Sep 5, 2006 . comparing the renal effects of Vioxx 25 mg versus Celebrex 200 mg conducted by. Dr. Andrew Whelton*, Adjunct Professor of Medicine at the .
http://www.merck.com/newsroom/vioxx/pdf/020-appendix_h_criticism_of_vioxxs_renal_safety_profile.pdf

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Vioxx alternatives: What if you can't take Celebrex or Bextra?
Also, compare the costs (from drugstore.com): COX-2 selective: Vioxx 25mg (30 tabs): $81.99. Celebrex 200mg (30 tabs): $79.99. Bextra 10mg (30 tabs): $83.99 .
http://www.kevinmd.com/blog/2004/10/vioxx-alternatives-what-if-you-cant.html

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Help for Arthritic Knees
. Inc., the manufacturer of Vioxx, conducted a study comparing the pain relief . received 12.5 or 25 milligrams (mg) of Vioxx, 200 mg of Celebrex or 4000 mg .
http://www.bestcmo.com/arthritic-knees.html

The Deadly Dozen Drugs Used To Treat Arthritis Pain
May 20, 2008 . Celebrex is known to cause death and Vioxx has the distinction of having more spontaneous adverse effects than any other drug -- per the .
http://www.painstudy.com/PainDrugs/index.htm

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What Now for Users of Vioxx, Celebrex, and Bextra? How to Use ...
In 2003, Vioxx, Celebrex, and Bextra reaped more than $6 billion in sales, . 50 mg twice-daily of Celebrex provided significant pain relief in comparison to . 4 to 6 hours.12-15 For Naprosyn, 200 or 250 mg twice-daily.16 For Voltaren, 25 mg .
http://medicationsense.com/articles/oct_dec_04/nsaids_more_safely.html

Cancer Chemotherapy - Chemotherapy Drugs, Chemo, COX-2 - Life ...
Both Celebrex and Vioxx are nonsteroidal anti-inflammatory drugs (NSAIDs) that are . Celebrex, 200-400 mg every 12 hours or. Vioxx, 12.5-25 mg once a day .
http://www.lef.org/protocols/prtcl-024.shtml

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Celebrex and Vioxx - arthritis pain relief without side effects?
Celebrex appears to have small but steady lead over Vioxx with 51% to 49% of scripts in the early part of 2000. . Royal Society of Chemistry 22 June 200. bullet. Long-term safety study shows 25% fewer physician consultations for arthritis patients taking celebrex compared with non-steroidal anti-inflammatory drugs such .
http://www.globalchange.com/celebrex.htm

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    OBJECTIVE: To compare efficacy among 1578 patients with osteoarthritis . (n= 269), celecoxib 200 mg (n=523), rofecoxib 12.5 mg (n=259), or rofecoxib 25 mg ( n=527) in a double blind trial [Vioxx, Acetaminophen, Celecoxib Trial (VACT2)].
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    Mar 20, 2012 . [25],[26]. X-ray evaluation is the "gold standard" in the diagnosis of osteoarthritis. . Celecoxib (Celebrex) 200mg/day, and rofecoxib (Vioxx) . Although the number of patients involved was small compared to those treated .
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  • Scientific Background for COX-2
    Untangling the Vioxx-Celebrex Controversy: A Story about Responsibility . [24] The crux of the discussion was based on Searle's NDA[25] , which is . safety of celecoxib (200 mg twice daily and 400 mg twice daily) compared to placebo in .
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  • (Celecoxib), Vioxx (Rofecoxib) - Quality Counts
    COX-2 Inhibitors (Celebrex™ (celecoxib)/Vioxx™ (rofecoxib)/Mobic (meloxicam), etc.) . in the pomegranate-fed animals, compared to control, particularly for COX -2. . Celebrex (Celecoxib) 200 mg Comparable To Vioxx (Rofecoxib) 25 mg in .
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A world without Vioxx: To COX-2 or not to COX-2?
Nov 11, 2004 . ib (Vioxx) from the market worldwide. This . long-term studies designed to compare either . the effects of celecoxib 200 mg, rofecoxib 25 .
http://www.ccjm.org/content/71/11/849.full.pdf

NSAIDS compared - Consumer Reports Health
and Pain. Comparing Drug Effectiveness, Safety, and Price . Three NSAIDs– Vioxx, Celebrex, and Bextra–were . Celebrex. No. Two. $162. Celecoxib 200 mg capsule. Celebrex. No. One. $133 . Diclofenac 25 mg delayed-release tablet .
http://www.consumerreports.org/health/resources/pdf/best-buy-drugs/Nsaids2.pdf

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FDA Perspective on Drug Safety
Placebo. Vioxx 25 mg. 11. Celebrex. December 31, 1998. Approval of New Drug . for Celebrex (celecoxib) for the signs and symptoms of osteoarthritis (200 . large long-term controlled clinical trials that have included a comparison of COX- 2 .
http://www.fda.gov/ohrms/dockets/ac/07/slides/2007-4290s1-01-01-FDA-Hertz.ppt

Reported Celebrex Side Effects and Adverse Reactions - Disability
Suspect drug(s): Celebrex Dosage: 200 mg, 2x/day. Start date: 2004-03-01 . professional (non-physician/pharmacist) from United Kingdom on 2010-02-25 . Other drugs received by patient: Vioxx; Lisinopril; Tamoxifen Citrate; Unspecified .
http://www.druglib.com/adverse-reactions_side-effects/celebrex/seriousness_disabling/

Defeat Diabetes: Rofecoxib (Vioxx) Increases Systolic Blood ...
May 23, 2003 . Rofecoxib (Vioxx) Increases Systolic Blood Pressure in . in which 404 patients were randomised to celecoxib 200 mg QD, rofecoxib 25 mg QD, .
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Provironum 25mg Schering . Celebrex 200mg, Pfizer labs, 120 capsules, $340 . of developing stomach ulcers compared with those taking Celebrex alone.
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usually Celebrex, 200 to 400 milligrams twice a day. Celebrex . utilize Vioxx, 25 milligrams per day or Bextra, 20 . compared to the same chemotherapy alone.
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Recommended dose: rofecoxib 25 mg per day; celecoxib 200 mg per day. . and rofecoxib compared with conventional nonsteroidal anti-inflammatory drugs . Adenomatous Polyp Prevention on Vioxx (APPROVe) trial indicating an increased .
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Efficacy of Rofecoxib, Celecoxib, and Acetaminophen in ...
list of Vioxx, Acetaminophen, Celecoxib Trial . (n = 96); rofecoxib, 25 mg/d (n = 95); celecoxib, 200 mg/d (n = 97); . weeks' treatment comparing COX-2 in- .
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COX-2 Inhibitors for the treatment of pain in OA and RA
Celecoxib 200 mg daily showed the same efficacy when compared with different active drugs (COX-2 inhibitors, nimesulide 100 mg daily and rofecoxib 25 mg daily; . Vioxx was withdrawn from the market September 2004. Efficacy: All drugs .
http://www.ihe.ca/documents/IP24Celecoxib.pdf

NSAIDs Conversion tools
In one trial (Francis KL, NEJM 347;26:1104) comparing celecoxib to . 200mg qd . 200mg bid. 200mg bid. Rofecoxib/Vioxx?#. 12.5mg qd. 25mg qd. 50mg qd for .
http://www.ashp.org/s_ashp/docs/files/NSAIDsConversiontools.pdf

NSAIDs Conversion tools
In one trial (Francis KL, NEJM 347;26:1104) comparing celecoxib to . 200mg qd . 200mg bid. 200mg bid. Rofecoxib/Vioxx?#. 12.5mg qd. 25mg qd. 50mg qd for .
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Hotline: September, 2004 - CHF and Vioxx.
From this data, the authors conclude that rofecoxib > 25mg/day was . was associated with an elevated risk of AMI compared with celecoxib (RR = 1.24, 95 % . OA with known hypertension to rofecoxib 25 mg or celecoxib 200 mg per day [2].
http://www.rheumatology.org/publications/hotline/0904chfvioxx.asp

Vioxx - The Internet Drug Database
In the APPROVe trial, Vioxx was compared to placebo (sugar-pill). . When a regime of Celebrex failed, I was given Vioxx 25mg with some relief, but not long .
http://www.iddb.org/drugs/vioxx/

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Review of the selective COX-2 inhibitors celecoxib and rofecoxib ...
Most of the relevant efficacy data comes from trials comparing celecoxib or rofecoxib to . concluded that rofecoxib (25 mg/d) was superior to celecoxib (200 mg/d) and . In the Vioxx Gastrointestinal Outcomes Research (VIGOR) study,9 8076 .
http://www.cjem-online.ca/v4/n4/p268

Hypertension Associated With Therapies to Treat Arthritis and Pain
regimen, rofecoxib (25 mg daily) increased the systolic BP by. 5 mm Hg . BP compared with patients treated with celecoxib 200 mg daily. . In the VIoxx .
http://hyper.ahajournals.org/content/44/2/123.full.pdf

NSAIDs Pose Death Risk for Heart-Attack Patients
Aug 17, 2006 . Compared to patients not taking any of these drugs, the risk of death was two . ( 25 milligrams or less a day) of Vioxx (rofecoxib) or 200 milligrams or . times as high among those taking more than 200 milligrams of Celebrex; .
http://www.dipyrone.com/news_article.html?tx_ttnews%5Btt_news%5D=3&tx_ttnews%5BbackPid%5D=69&cHash=b75b40bd83

 

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